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KMID : 0613820100200060964
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Journal of Life Science
2010 Volume.20 No. 6 p.964 ~ p.967
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Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Escherichia coli Isolated from Diseased Animals in Korea
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Shin Dong-Ho
Lim Suk-Kyung
Kim Ha-Young
Byun Jae-Won
Jung Byeong-Yeal
Kim Dae-Keun
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Abstract
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Plasmid-mediated quinolone resistance (PMQR) determinants have been contributed to quinolone resistance of gram-negative bacteria worldwide. However, little data on the prevalence of these determinants in bacteria from animals are available in Korea. In this study, the prevalence of PMQR genes was investigated with E. coli originating from diseased animals. Among 55 E. coli tested, 11 showed PMQR genes by PCR. The most prevalent genotype was qepA (14.5%), followed by aac(6′)-Ib-cr (7.3%) and qnrS (1.8%). Interestingly, two isolates with PMQR genes did not show quinolone resistance in this study. The isolates exhibited higher fluoroquinolone resistance in aac(6′)-Ib-cr in combination with qnrS or qepA compared with aac(6′)-Ib-cr only. In a conjugal transfer test, PMQR genes were transferred from donor to recipient.
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KEYWORD
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Plasmid-mediated quinolone resistance (PMQR), qnrS, aac(6′)-Ib-cr, qepA
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